A Penn Medicine study shows that patients taking semaglutide continue to experience meaningful appetite control and reduced calorie intake even after more than a year of treatment, helping sustain weight loss even as food noise begins to increase. “Many patients worry that their medication has stopped working if they notice some return of hunger after the first several months,” said Jena Shaw Tronieri, PhD, a senior research investigator at the Center for Weight and Eating Disorders. “Our findings show that even when people feel some of those sensations returning, semaglutide continues to help them eat less. That sustained reduction in calorie intake appears to be a key reason why weight loss is maintained over time.”